24 Feb What Do Grapefruits and CBD have in Common?
Have you ever been told not to take your medication with grapefruit? Compounds in grapefruit interact with the metabolism of many medications. CBD can interact with medications in an even stronger way than grapefruit. While CBD is safe for use and consumption and poses few risks, it can inhibit the cytochrome P450 enzyme system which is responsible for the metabolizing of many drugs. If your doctor or pharmacist has told you not to eat grapefruit with your medication, this may be a great indicator as to whether you are a good candidate for CBD oil.
The Cytochrome P450 Pathway
The Cytochrome P450 enzyme system is located within the liver. This system is responsible for metabolizing potentially toxic compounds, including 60% of the pharmaceutical drugs that are consumed. Doctors prescribe dosages of medications using calculations of the average amount of time it takes for specific medications to be processed through the cytochrome P450 system. Certain substances, including CBD, have the ability to affect processing times within this system, affecting the rates that drugs metabolize. This can lead to higher levels of certain drugs in the system at one time and unwanted side effects. Therefore, it is very important to check with your doctor if you are taking medications before taking CBD. Your doctor may want to make alterations to your dosage to allow for the addition of CBD.
Medications that may interact with CBD:
• Calcium channel blockers
• Beta blockers
• Angiotension II blockers
• Proton Pump Inhibitors
• Non-Steroidal Anti-Inflammatory Drugs
• Oral hypoglycemic agents
• HMG CoA reductase inhibitors
• HIV antivirals
• Immune modulators
Having a discussion with your doctor regarding your medications and CBD will help insure that you are receiving the correct dosage in order to achieve the best possible outcome for your health. However, if your physician is unwilling to discuss CBD, please remember to take the grapefruit test.